Genetic Health Risk reports?provide genetic risk information based on assessment
of specific
genetic variants associated with increased risk for certain health conditions. They do
not diagnose
health conditions, determine current state of health, or be used to make medical
decisions.
Having a risk variant?does not mean you will definitely develop a health
condition.
Similarly, absence of variants tested does not rule out the chances of developing the
condition. The
reports may not detect all genetic variants related to a disease.
Environmental and lifestyle factors?may also affect the risk of developing health
conditions.
These reports do not replace visits to a healthcare professional.?Please consult
with an
genetic counselor, board-certified clinical molecular geneticist, or equivalent health
care
professional if you think you might have a health condition.
We encourage you to talk to a genetic counselor
There is a lot to consider before genetic testing. Although these tests can provide
important
information about health risk, they can also raise worries by learning about genetic
risks for these
diseases. These tests also have certain limitations assessing genetic risk information
based on
specific genetic variants.
Personal health behaviors and family health history should all be taken into account on
decision
about whether to have a genetic test. Talk to your healthcare provider or search for a
genetic
counselor near you by visit website of the National Society of Genetic Counselors (http://www.aboutgeneticcounselors.com).
Possible test results of Genetic Health Risk reports
Variants not detected: You do not have the variant(s) we tested. These tests
do not cover
all possible genetic variants related to a health condition. Non-genetic factors
such as age,
sex and family history may also affect your risk.
Variants detected: You have one or more of the variants we tested. The risk
of the
condition may increase based on your genetic results. This does not mean you will
definitely
develop a disease. Other factors may also affect your risk.
Result not determined: Your result could not be determined. This can be
caused by random
test error or other factors.
In some cases, the laboratory may not be able to process you sample. If this happens, we
will notify you by email or private message and provide you with one free replacement
kit.
Other companies offering genetic risk tests may include different variants for the same
health condition. This means that it's possible to get different results using a test
from a different company.
You will be asked whether you want to receive certain Genetic Health Risk reports
Some reports are about diseases that may not be effectively treated or cured at present. Others
may have effective treatment or prevention options, but these actions may carry their own health
risks. If you feel anxious or have diagnosed with anxiety or depression, you may be upset by
learning genetic risks for these diseases, and about genetic risks for family members who share
DNA.
You can choose to exclude some reports individually from your report before your results are
returned to you. Additional information about these reports will provided through report
configuration.
Select a Condition
Late-Onset Alzheimer's Disease
What to know about:
Late-Onset Alzheimer's Disease?and our test
Alzheimer's disease, also known as dementia, is the most common type of senile
dementia, accounting for 50% of all senile dementia cases. It occurs in the elderly
and pre-elderly as progressive cognitive dysfunction and behavioral impairment
characterized by degenerative lesions in the central nervous system. Clinically, the
disease manifests as memory impairment, aphasia, apraxia, agnosia, visuospatial
impairment, damage to abstract thinking and computational power, personality and
behavioral changes, etc.
Typical signs and symptoms
Short-term memory loss
Trouble identifying time, place and people
Mood and personality changes
Confusion with place or time
Lose self-care ability
Other Influence Factors
Age
Sex
Family history
Heart health
Smoking
Education
Mental and psychological factors
When it develops
Late-onset Alzheimer's disease develops over age 65.
How it's treated
There is currently no cure for this condition.
Psychopathological symptoms controlling or medication may be used to
delay or ease symptoms.
What do we test
Tests for the?ε4?variant in the APOE gene associated with an increased risk of developing late-onset Alzheimer's disease.
Absence of a?ε4?variant tested does not rule out the presence of other genetic variants that may related to late-onset Alzheimer's disease.
Ethnicities
The APOE ε4 variant and the risk estimates are mainly based on people of?European?descent.