亚洲精品午夜精品,日本二手网站,国产AⅤ爽AV久久久久成人社区,日本一二三区不收费av

使用 WeGene 需要啟用 Cookies, 請啟用后刷新頁面獲得更好的體驗

A potential bug report: incomplete information in the paternal haplogroup section

I did a 23andMe test a while ago and I've been playing around with the functions (mostly the ancestry analysis module) offered on WeGene recently using my 23andMe data. It's quite nice to get a finer resolution of my ancestry composition among the ethnic groups within the general Chinese population so that I can have a better understanding of my ancestry/family history. However, the information shown in the paternal haplogroup section seems somewhat incomplete. I can see my Y chromosome haplogroup is classified as J2, which is consistent with the result provided by 23andMe (though, as a Han Chinese and an evolutionary biology grad student, this is a little bit surprising to me in the first place, but then got me slightly more interested in exploring my ancestry a bit more), but all the content that is supposed to be presented below (such as the Migration Routes, Haplogroup, Age, etc.) are just blanks (as shown in the attached figure).
?

paternal_haplogroup_information.png



I'm not sure if this is caused by any problem with the front end (though doesn't seem it's the case judging from a inspection of the HTML code) and/or the back end (no available information for this haplogroup in the database) or something more cryptic, but I just wanted to post this issue here for your information.
?
Thanks,
J
2017-01-12 ? IP屬地美國
按熱門排序    按默認排序

7 個回復

費力科思 - WeGene勤雜工
I think we have to call Dr. Chuanchao @wang for help:)
wang - 哈佛醫學院、德國馬普所分子人類學博士后
Hi thanks for reporting the bug.
?
Could you possibly give me more information about your haplogroup that 23andme generates for you since we use a different version of Y tree to name the lineage, which is confusing sometimes?
Could you show the paternal lineage tree following the steps here to check if there are mutations really matched on this particular J2 haplogroup??
http://www.sofreetech.com/question/1559
Thanks for the prompt reply! Below (attached as figures) are the corresponding results provided by 23andMe and WeGene.

23andMe_J2.png


23andMe_J2_phylogeny.png

Result from 23andMe
?

WeGene_phylogeny_SNPs.png

Result from WeGene
?
To confirm this haplogroup assignment, I tried some third party programs previously, such as yhaplo,?and they all gave me the same result.

I also checked some SNPs by myself and they all look about right. The major ones are listed as follows.
?
SNP ? ?rsid ? ?chromosome ? ?position ? ?genotype
M304/Page16/PF4609 ? ?rs13447352 ? ?Y ? ?22749853 ? ?C
CTS5628/PF4555 ? ?rs17307231 ? ?Y ? ?16401405 ? ?G
P209/PF4584 ? ?rs17315835 ? ?Y ? ?19179335 ? ?C
CTS5280/PF4550 ? ?rs17307175 ? ?Y ? ?16180103 ? ?G
F2502/PF4564 ? ?rs17222412 ? ?Y ? ?17495914 ? ?A
M172/Page28/PF4908 ? ?rs2032604 ? ?Y ? ?14969634 ? ?G
?
So I guess the inference of my general paternal haplogroup should be correct, but there may be some issues with the front-end visualization on WeGene. I can share my 23andMe raw data with you if you want.
?
Thanks,
J
wang - 哈佛醫學院、德國馬普所分子人類學博士后
thanks for posting.the haplogroup?assignments are consistent in suggesting you belong to J. I agree with you that the problem is front-end visualization but not our scientific interpretation. I will contact our IT department to figure out what happened to the visual. Thanks.?
wang - 哈佛醫學院、德國馬普所分子人類學博士后
I just get the feedback that we have not included haplogroup J into our visualizations because this lineage is so rare in Chinese. We will update our system to also add those rare haplogroups into it.Thanks!?
Thanks for the confirmation! Glad that I can contribute a little to the further improvement of this good platform.
?
As you mentioned that the haplogroup J2 is very rare among Han Chinese populations, I'm quite curious about its putative migration routes and history in China, and how did this presumably Middle East originated Y chromosome haplogroup/gene pool introgressed into Han Chinese population. From the limited amount of publications I could find about the distribution of this haplogroup among the populations (especially Han Chinese populations) in China/East Asia, it seems that this haplogroup constitute a significant proportion of some minority populations from Northwest China (including Uyghurs, Uzbeks, Tajiks, Hui, etc.), but a fairly low (1-5%) though pretty homogenized distribution among the Han Chinese populations from several Northwest provinces (Xinjiang, Qinghai, Gansu, Ningxia, etc.). I guess one of the plausible hypothesis would be that there were small but constant migration flows from the central Asia populations to Northwest China long before the Islamic expansions, though I'm not sure whether this hypothesis is consistent with the fact that this haplogroup is even much rarer (if any) in other Han Chinese populations that are more Southeastern, considering that they had inhabited Gansu and Shaanxi that long ago.

It would be great if I could learn more about this from expert like you.
?
best,
J
wang - 哈佛醫學院、德國馬普所分子人類學博士后
I am sharing with you a paper explaining the present-day fragmented distribution of West Eurasian lineages in China:
http://mbe.oxfordjournals.org/content/28/1/717.short
Zhong H, Shi H, Qi XB, Duan ZY, Tan PP, Jin L, Su B, Ma RZ. Extended Y chromosome investigation suggests postglacial migrations of modern humans into East Asia via the northern route. Molecular biology and evolution. 2011 Jan 1;28(1):717-27.

要回復問題請先登錄注冊

  • <track id="ffr4e"></track>

      <dfn id="ffr4e"></dfn>

      主站蜘蛛池模板: 洛南县| 台州市| 遂川县| 高台县| 宜兰市| 吴旗县| 夏邑县| 深州市| 苍南县| 夏邑县| 四川省| 林周县| 鹤山市| 惠安县| 天镇县| 钟山县| 泽普县| 登封市| 会宁县| 克山县| 亳州市| 平邑县| 西峡县| 繁昌县| 上思县| 灵宝市| 定南县| 绥中县| 泰州市| 延津县| 灵寿县| 礼泉县| 平度市| 女性| 从化市| 如东县| 文昌市| 富民县| 沙河市| 法库县| 丰城市|