zhengqiang - 勤奮學(xué)習(xí) 高原反應(yīng)

高原反應(yīng)檢查哪些位點(diǎn)，準(zhǔn)確性如何？

2014-11-25 ? IP屬地深圳

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大灰狼

- Don't worry, Be happy~

關(guān)于藏人EPAS1和EGLN1受到選擇適應(yīng)高海拔的文章很多呀，nature，science各種灌水。

舉幾個(gè)例子：
Simonson T S, Yang Y, Huff C D, et al. Genetic evidence for high-altitude adaptation in Tibet[J]. Science, 2010, 329(5987): 72-75.

Yi X, Liang Y, Huerta-Sanchez E, et al. Sequencing of 50 human exomes reveals adaptation to high altitude[J]. Science, 2010, 329(5987): 75-78.
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Beall C M, Cavalleri G L, Deng L, et al. Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders[J]. Proceedings of the National Academy of Sciences, 2010, 107(25): 11459-11464.

Xu S, Li S, Yang Y, et al. A genome-wide search for signals of high-altitude adaptation in Tibetans[J]. Molecular biology and evolution, 2011, 28(2): 1003-1011.

Peng Y, Yang Z, Zhang H, et al. Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas[J]. Molecular biology and evolution, 2011, 28(2): 1075-1081.

Lorenzo F R, Huff C, Myllym?ki M, et al. A genetic mechanism for Tibetan high-altitude adaptation[J]. Nature genetics, 2014.

Huerta-Sánchez E, Jin X, Bianba Z, et al. Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA[J]. Nature, 2014, 512(7513): 194-197.?
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