這研究還在搞呢，BRCA相關的SNP少說有1000多個，而且種族差異很大，不確定東亞人里是否有乳腺癌和宮頸癌的篩查/診斷意義，23andMe報告里只有三個位點，僅適用于德系猶太人。
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以下引自23andMe BRCA1/BRCA2 (Selected Variants)報告，供參考：
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Specific genetic variants in the BRCA1 and BRCA2 genes are associated with an increased risk of developing certain cancers, including breast cancer (in women and men) and ovarian cancer. These variants may also be associated with an increased risk for prostate cancer and certain other cancers. This test includes three genetic variants in the BRCA1 and BRCA2 genes that are most common in people of Ashkenazi Jewish descent.
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However, more than 1,000 variants in the BRCA1 and BRCA2 genes are known to increase cancer risk, so you could still have a variant not included in this test.?In addition, most cases of male breast cancer and prostate cancer are not caused by inherited variants, so men without a variant are still at risk of developing these cancers. It's important to continue with any cancer screenings your healthcare provider recommends.
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Intended Uses：
Tests for three specific genetic?variants: the?185delAG?and?5382insC?variants in the BRCA1?gene?and the?6174delT?variant in the BRCA2 gene. These variants are associated with an increased risk of developing certain cancers.
Provides information on whether a person's genetic result is associated with an increased risk for breast and ovarian cancer and may be associated with an increased risk for prostate cancer and certain other cancers.

Limitations
Does?not?test for all possible variants in the BRCA1 and BRCA2 genes. More than 1,000 variants in these genes are known to increase cancer risk. Only three of those variants are included in this test.
Does?not?test for variants in other genes linked to?hereditary cancers.
Does?not?account for non-genetic factors, like environment and lifestyle, that influence overall cancer risk.
The interpretation of your genetic result depends on the sex you reported in your account settings.

Important Ethnicities
The variants included in this test are most commonly found in people of?Ashkenazi?Jewish?descent. In 23andMe customers of other ethnicities, between 0% and 0.1% of individuals has one of the three variants in this report.
This test does?not?include the majority of BRCA1 and BRCA2 variants found in people of other ethnicities. Therefore, a "variants not detected" result is less informative for people with no Ashkenazi Jewish ancestry.
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在知道局限性之后，有微解讀可以看一下：
http://www.sofreetech.com/crowdsourcing/details/153
http://www.sofreetech.com/crowdsourcing/details/152?

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最后，期待東亞人的研究有進展吧

同問